Free Ebook BookAntifolate Drugs in Cancer Therapy (Cancer Drug Discovery and Development)

[Ebook.Bcq3] Antifolate Drugs in Cancer Therapy (Cancer Drug Discovery and Development)

[Ebook.Bcq3] Antifolate Drugs in Cancer Therapy (Cancer Drug Discovery and Development)

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Book Details :
Published on: 1999-01-22
Released on: 1999-01-22
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Antifolates are an important class of anticancer drugs originally developed as anti leu kemic agents, but now used, usually in combination with other drugs, for the treatment of a wide range of tumors, notably carcinomas of the head and neck, breast, germ cell tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and osteogenic sar comas. 5-Fluorouracil and its prodrugs also target, in part, the folate-dependent enzyme, thymidylate synthase. Furthermore, folate supplementation in the form of leucovorin, modulates 5-fluororuacil activity. 5-Fluorouracil is widely used in the treatment of colorectal and gastric cancer and in combination for other solid tumors such as breast and head and neck cancers. Ongoing clinical trials with the newer antifolates suggest that the range of solid tumors where these agents will be of use may broaden further. Half a century ago, interesting scientific and clinical discoveries suggested that folie acid was a vitamin involved in vital cellular metabolic processes. The folate analogs, aminopterin and methotrexate, were synthesized by the American Cyanamid Company in an attempt to interfere with these processes and were shown to have anticancer activity by Farber and his colleagues. Hence, the principle of antimetabolite therapy for the treatment of cancer was established. Biomedical research over the following years led to a deeper understanding of the complex biochemical pharmacology of folates and antifolates. Selective antimicrobial agents were discovered, but more tumor-selective anticancer agents did not immediately emerge. The Little Known Difference Between Folate and Folic Acid This statement was made: While folic acid is often considered to be a supplemental form of folate there is an important distinction between these two different ... Headaches Hives and Heartburn: Could Histamine Be the Cause? Red wine. Aged cheese. Citrus fruits. Sauerkraut. Bacon. These foods are frequently consumed by those on a healthy whole foods diet and are often found in a variety ... Targeting multidrug resistance in cancer : Article ... Anticancer drugs can fail to kill cancer cells for various reasons. Drugs are usually given systemically and are therefore subject to variations in absorption ... Personalized genotype-directed therapy for advanced non ... INTRODUCTION Treatment for patients with metastatic non-small cell lung cancer (NSCLC) has historically consisted of systemic cytotoxic chemotherapy. Chemotherapy ... Sirolimus - Wikipedia Sirolimus (INN/USAN) also known as rapamycin is a macrolide compound that is used to coat coronary stents prevent organ transplant rejection and to treat a rare ... Trimethoprim: Indications Side Effects Warnings - Drugs.com Easy to read patient leaflet for trimethoprim. Includes indications proper use special instructions precautions and possible side effects. History of cancer chemotherapy - Wikipedia The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. Cancer drug development has exploded since ... -TMU Today: 131 . . joycechin December 23 2016 02:53 PM ... PPT Anticancer drugs PowerPoint presentation free to ... Buy Anticancer Drugs - Use Cytarabine Sutent Medicine to treat Cancer - Cancer is also known as a malignant tumor. Cancer is a group of diseases relating abnormal ...
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